Dr. de Grey and his outstanding international editorial board have the opportunity to further explore and advance the science, and perhaps achieve the ultimate goal of slowing or reversing the process of aging.
This fully indexed MEDLINE journal covers:
•Cardiovascular aging
•Cell immortalization and senescence
dna and cell biology
DNA and Cell Biology covers the latest research in the field of DNA and cell biology. This peer-reviewed journal includes original reports and cutting-edge reviews on:
•Gene Structure, Function, and Regulation, including topics on genomic organization; the role of histones in gene regulation; the molecular mechanisms of cell activation; the role of NF-kB in cell biology; and the interaction of viral genes with the cell replication apparatus
•Molecular Medicine, featuring molecular pathogenesis; genetic approaches to cancer and autoimmune diseases; HIV immunopathogenesis; and innovative approaches to studying inherited diseases
•Comparative Biology, such as cell-cell signaling in bacteria, plants, and animals; gene orthologue comparisons; and model systems development
•Immunology, covering mechanisms initiating or regulating transcriptional, translational or epigenetic control of gene expression in the context of innate or adaptive immune cell function. Special emphasis is on responses to infectious disease agents and transformed cells, and on comparative immunobiology
Some of the rejuvenation techniques under research are as mentioned under;
•Cloning/ESCs
•DNA damage/repair
•Gene targeting, gene therapy, and genomics
•Growth factors
•Immunology
•Invertebrate lifespan
•Neurodegeneration
•Tissue engineering
•Public policy, social context
•And much more ...
CELLULAR REPROGRAMMING
Cellular Reprogramming, (formerly Cloning and Stem Cells), reflects the new focus in this evolving field. Advances in reprogramming cellular mechanisms are transforming biomedical research and should offer new insights on the etiology, development, and potential treatment of various diseases. Cloning and Stem Cells, which has long focused on many aspects of cellular reprogramming, has been renamed in recognition of the rapidly increasing importance of this particular biological field of study. The Journal will emphasize novel approaches for understanding the cellular and molecular mechanisms that underlie the phenomenon of reprogramming. The Journal will continue to publish papers concerned with:
• Somatic cell nuclear transfer and reprogramming in early embryos
• Embryonic stem cells
• Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos)
• Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based
therapies
• Epigenetics
• Adult stem cells and pluripotency
• And much more…
TISSUE ENGINEERING
Angiogenic control has proven to be one of the most difficult aspects of tissue engineering to master. This presents broad-based anatomic and physiologic challenges to the tissue engineer. Key controllers of angiogenesis have been formed to be mechanical forces, small molecules (drugs and growth factors), co-culture with non-vascular cells, biomaterials, and stem cells. This volume addresses vascular assembly techniques and the transplantation of microvascular networks.
Advances in Tissue Engineering, Volume 1: Angiogenesis presents leading-edge research and insight on:
• The mechanisms of angiogenesis, as studied in developmental biology models
• The application of systems biology to help us understand how choke points might be controlled by drugs or other approaches
• The physiological functioning of engineered capillaries, venules, and arterioles
• Creation of networks that have large enough arterial and venous components to enable direct anastomosis to host vessels
• Vascular assembly techniques and transplantation of microvascular networks
“The Advances in Tissue Engineering book series is an important new tool to students, scientists, and engineers interested in the field of tissue engineering and regenerative medicine. It identifies the important issues of the field and provides the reader with state of the art knowledge which can then be applied to new solutions.”
Joseph. P. Vacanti, MD
Harvard Stem Cell Institute
Massachusetts General Hospital
“Vascular growth and stem cells undoubtedly play a central role in normal tissue development and growth. The grand challenge is to figure out how to transform the ever-expanding knowledge of key biomolecular signals that regulate tissue morphogenesis into therapies that promote functional tissue regeneration. The Advances in Tissue Engineering book series begins with a state-of-the-art collection of the latest scientific advances in therapeutic angiogenesis and stem cell delivery strategies that will be needed to enable development of the next generation of tissue regenerative technologies.”
HUMAN GENE THERAPY
Human Gene Therapy is the definitive peer-reviewed rapid-publication journal covering all aspects of human gene therapy. The Journal publishes scientific papers on original investigations into the transfer and expression of genes in mammals, including humans. Improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, are covered.
Other key features include a continuously updated directory of human gene marker and gene therapy clinical protocols, as well as ethical/legal/regulatory papers related directly to the area of gene transfer into humans.
Stem Cells and Development focuses on stem cells of all tissue types and their potential therapeutic applications. The Journal continues its tradition of providing a forum for animated discussion of contentious issues in conventional medicine.
Stem Cells and Development covers:
- Controversial issues on stem cell research
- Stem cells of all tissues and organs
- Embryogenesis and adult counterparts of this process
- Physical processes linking stem cells, primary cell function, and structural development
Transition from genes to physical effects: hypotheses and data - Development of vasculature, CNS, and other germ layer development and defects
- Processes included in development: how the molecules work
- Pluripotentiality of adult stem cells
- The role of various mediators and how genetic factors affect development at a physical level
- Correspondence and concise, comprehensive reviews
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